Methods in Signal Transduction Series
About the Book Series
The concept of signal transduction is now long established as a central tenet of biological sciences. Since the inception of the field close to fifty years ago, the number and variety of signal transduction pathways, cascades and networks have steadily increased and now constitute what is often regarded as a bewildering array of mechanisms by which cells sense and respond to extracellular and intracellular environmental stimuli. It is not an exaggeration to state that virtually every cell function is dependent on the detection, amplification and integration of these signals. Moreover, there is increasing appreciation that in a many disease states, aspects of signal transduction are critically perturbed.
Our knowledge of how information is conveyed and processed through these cellular molecular circuits and biochemical switches has increased enormously in scope and complexity since this series was initiated fifteen years ago. Such advances would not have been possible without the supplementation of older technologies, drawn chiefly from cell and molecular biology, biochemistry, physiology and pharmacology, with newer methods that make use of sophisticated genetic approaches as well as structural biology, imaging, bioinformatics and systems biology analysis.
The overall theme of this series continues to be the presentation of the wealth of up to date research methods applied to the many facets of signal transduction. Each volume is assembled by one or more editors who are pre-eminent in their specialty. In turn, the guiding principle for editors is to recruit chapter authors who will describe procedures and protocols with which they are intimately familiar in a reader-friendly format. The intent is to assure that each volume will be of maximum practical value to a broad audience, including students and researchers just entering an area, as well as seasoned investigators.
Open Access makes published academic research freely and permanently available online for anyone, anywhere. OA publications are downloaded 7 times more often, cited 50% more, and mentioned online 10 times more often. Upon publication, OA content is made available in digital format to read and download under a Creative Commons license.
Options are available to editors, authors and contributors to the series. See https://www.routledge.com/our-products/open-access-books/taylor-francis-oa-books for more information and frequently asked questions with respect to these options or contact Chuck Crumly, Senior Acquisitions Editor, at [email protected] for more details.
TRP-Mediated Signaling
1st Edition
Edited
By Michael Xi Zhu
December 12, 2024
The field of transient receptor potential (TRP) channels has gained momentum in recent years not only because of the 2021 Nobel Prize in Physiology or Medicine awarded to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch, but also because of the growing...
Immune Cells, Inflammation, and Cardiovascular Diseases
1st Edition
Edited
By Shyam S. Bansal
May 27, 2024
Inflammation, once considered a physiological response to foreign pathogens, is now recognized as a crucial pathological player in the initiation and progression of several chronic diseases, including diabetes, obesity, cancer, Alzheimer’s disease, Parkinson’s disease, and many others. Considering ...
Lung Biology and Pathophysiology
1st Edition
Edited
By Yutong Zhao
February 20, 2024
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway ...
Nonclassical Ion Channels in the Nervous System
1st Edition
Edited
By Xu Tian-le, Long-Jun Wu
September 25, 2023
Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, ...
Neuron Signaling in Metabolic Regulation
1st Edition
Edited
By Qingchun Tong
June 26, 2023
This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis ...
Opsin-free Optogenetics: Technology and Applications
1st Edition
Edited
By Yubin Zhou, Kai Zhang
December 14, 2022
Optogenetics represents a breakthrough technology capable of dynamically modulating molecular and cellular activity in live cells with high precision. This transformative technology made it possible to reversibly interrogate protein actions, cellular events, and animal behaviors with a simple flash...
Lipid-Mediated Signaling
1st Edition
Edited
By Eric J. Murphy, Eric Murphy, Thad Rosenberger, Thad A. Rosenberger
September 12, 2017
As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade’s worth of advances in ...
TRP Channels
1st Edition
Edited
By Michael X. Zhu
September 12, 2017
The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic ...
Signal Transduction in the Retina
1st Edition
Edited
By Steven J. Fliesler, Oleg G. Kisselev
December 26, 2007
In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents ...
Analysis of Growth Factor Signaling in Embryos
1st Edition
Edited
By Malcolm Whitman, Amy Sater
August 15, 2006
Developmental biologists have been driven to investigate growth factor signaling in embryos in order to understand the regulatory mechanisms underlying a given developmental process. Thus, it is critical to explore the technical methods and experimental designs for growth factor signaling in ...
Signaling Through Cell Adhesion Molecules
1st Edition
By Jun-Lin Guan
May 20, 1999
The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and ...
G ProteinsTechniques of Analysis
1st Edition
Edited
By David R. Manning
May 19, 1999
Incorporating a bench-top format, G Proteins: Techniques of Analysis covers essential methods - with a commitment to those techniques of proven and current utility.G Proteins: Techniques of Analysis includes expression and functional analysis of G proteins; evaluation of covalent modifications and...